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91955

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Genistein

BioChemika, ≥98.0% (HPLC)

Synonym:4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number:446-72-0
Linear Formula:C15H10O5
Molecular Weight:270.24
Beilstein Registry Number:263823
EC Number:207-174-9
MDL number:MFCD00016952

Description

Biochem/physiol ActionsInhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.
Other NotesInhibitor of protein-tyrosine kinases1

Properties

product lineBioChemika
assay≥98.0% (HPLC)
solubilitychloroform/methanol (9:1): 10 mg/mL, clear
storage temp.−20°C

Safety

Personal Protective EquipmentEyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements22-24/25
WGK Germany3
RTECSNR2392000

Related Products

Replaced byG6649, Genistein

References

Cited Reference1. T. Akiyama, H. Ogawara Meth. Enzymol. 201, 362, (1991) Abstract
referenceAkiyama, T., et al., Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262, 5592-5595, (1987)
 O'Dell, T.J., et al., Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353, 558-560, (1991)
 Huang J., et al., Genistein inhibits protein histidine kinase. J. Biol. Chem. 267, 15511-15515, (1992)
 Hakansson, G., and Allen, J.F., Histidine and tyrosine phosphorylation in pea mitochondria: evidence for protein phosphorylation in respiratory redox signalling. FEBS Lett. 372, 238-242, (1995)
 Igarashi, M., and Komiya, Y., Tyrosine phosphorylation and immunodetection of vinculin in growth cone particle (GCP) fraction and in GCP-cytoskeletal subfractions. J. Neurosci. Res. 30, 266-274, (1991)
 Li, Y., and Sarkar, F., Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Lett. 186, 157, (2002)
 Wietrzyk, J., et al., Antiangiogenic and antitumour effects in vivo of genistein applied alone or combined with cyclophosphamide. Anticancer Res. 12, 3893-3896, (2001)
MerckMerck 13,4402
BeilsteinBeil. 18,V,4,594